addrbookFor publishers
← The evidence ledger

Evidence row 119405

Observed , by baseline/1.

Kind
listing
About
source_record x402_bazaar:https://saylorinnovations.com/api/bio/target-search
Recorded
Previous row
None: the first of its kind about this subject
Body SHA-256
46bc31ef087b866b7656de99f38e2371538d086fc6d63ddce54d5a45f3ebad76
Leaf
0xada1b52438a9a47ed3ef8071211e8a1a37afdfc673d309c10c08e41e2f994856

What was observed

{
  "endpoints": [
    [
      "x402",
      "https://saylorinnovations.com/api/bio/target-search"
    ]
  ],
  "name": "Saylor Innovations Data Desk",
  "owner_address": "0xa2a8df0f7caabea4e120a2568118f141569fc8aa",
  "raw": {
    "accepts": [
      {
        "amount": "10000",
        "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
        "extra": {
          "assetTransferMethod": "eip3009",
          "facilitatorOnly": true,
          "memo": "saylor:datadesk:opentargets-targ",
          "name": "USD Coin",
          "note": "Base settles through an x402 facilitator. Send payload.signature and payload.authorization (EIP-3009); there is no self-submitted path on this network.",
          "version": "2"
        },
        "maxTimeoutSeconds": 120,
        "network": "eip155:8453",
        "payTo": "0xA2A8dF0f7CaaBEa4e120a2568118f141569fc8aa",
        "scheme": "exact"
      },
      {
        "amount": "10000",
        "asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
        "extra": {
          "feePayer": "BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F",
          "memo": "saylor:datadesk:opentargets-targ",
          "reference": "Ajx85wsdPC6SJZLGiK7Fg9b35QDfBdmqZpYBx5tTtybK",
          "session": "eyJhcnRpY2xlSWQiOiJkYXRhZGVzazpvcGVudGFyZ2V0cy10YXJnZXQiLCJyZWZlcmVuY2UiOiJBang4NXdzZFBDNlNKWkxHaUs3Rmc5YjM1UURmQmRtcVpwWUJ4NXRUdHliSyIsInJlY2lwaWVudCI6IjdMU2pmckpmOGZOc0I4VkE5dTdOM1dFbjI1c21RTHBvYjNTdnlVdlhhY3k3IiwibWludCI6IkVQakZXZGQ1QXVmcVNTcWVNMnFOMXh6eWJhcEM4RzR3RUdHa1p3eVREdDF2IiwibWluQW1vdW50IjoxMDAwMCwiZXhwIjoxNzkyMjI1ODQ0MTk2fQ.1ENY0Tqt75ZTF0nau2wfRrHrFF2Uf11I7NzV6lPx3DI"
        },
        "maxTimeoutSeconds": 120,
        "network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
        "payTo": "7LSjfrJf8fNsB8VA9u7N3WEn25smQLpob3SvyUvXacy7",
        "scheme": "exact"
      }
    ],
    "description": "Gene and drug-target lookup from Open Targets - Ensembl id, location, function, tractability by modality and top associated diseases with scores",
    "extensions": {
      "bazaar": {
        "info": {
          "input": {
            "method": "GET",
            "queryParams": {
              "q": "BRCA1"
            },
            "type": "http"
          },
          "output": {
            "example": {
              "other_matches": [
                {
                  "description": "BRCA1 pseudogene 1",
                  "ensembl_id": "ENSG00000267595",
                  "symbol": "BRCA1P1"
                },
                {
                  "description": "BRCA1 interacting DNA helicase 1",
                  "ensembl_id": "ENSG00000136492",
                  "symbol": "BRIP1"
                },
                {
                  "description": "BRCA1 associated deubiquitinase 1",
                  "ensembl_id": "ENSG00000163930",
                  "symbol": "BAP1"
                },
                {
                  "description": "BRCA1 associated RING domain 1",
                  "ensembl_id": "ENSG00000138376",
                  "symbol": "BARD1"
                }
              ],
              "query": "BRCA1",
              "source": "Open Targets Platform",
              "top_match": {
                "associated_disease_count": 1324,
                "biotype": "protein_coding",
                "ensembl_id": "ENSG00000012048",
                "function": "E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microt…",
                "location": {
                  "chromosome": "17",
                  "end": 43170245,
                  "start": 43044292,
                  "strand": "NEGATIVE"
                },
                "name": "BRCA1 DNA repair associated",
                "symbol": "BRCA1",
                "top_diseases": [
                  {
                    "association_score": 0.844,
                    "disease": "breast cancer",
                    "efo_id": "MONDO_0007254"
                  },
                  {
                    "association_score": 0.828,
                    "disease": "hereditary breast ovarian cancer syndrome",
                    "efo_id": "MONDO_0003582"
                  },
                  {
                    "association_score": 0.817,
                    "disease": "Fanconi anemia, complementation group S",
                    "efo_id": "MONDO_0054748"
                  },
                  {
                    "association_score": 0.811,
                    "disease": "ovarian cancer",
                    "efo_id": "MONDO_0008170"
                  },
                  {
                    "association_score": 0.8,
                    "disease": "breast neoplasm",
                    "efo_id": "MONDO_0021100"
                  },
                  {
                    "association_score": 0.799,
                    "disease": "breast-ovarian cancer, familial, susceptibility to, 1",
                    "efo_id": "MONDO_0011450"
                  },
                  {
                    "association_score": 0.788,
                    "disease": "ovarian neoplasm",
                    "efo_id": "MONDO_0021068"
                  },
                  {
                    "association_score": 0.779,
                    "disease": "cancer",
                    "efo_id": "MONDO_0004992"
                  }
                ],
                "tractability_by_modality": {
                  "AB": [
                    "GO CC high conf"
                  ],
                  "PR": [
                    "UniProt Ubiquitination",
                    "Database Ubiquitination",
                    "Small Molecule Binder"
                  ],
                  "SM": [
                    "Druggable Family"
                  ]
                }
              },
              "url": "https://platform.opentargets.org/target/ENSG00000012048"
            },
            "type": "json"
          }
        },
        "schema": {
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "properties": {
            "input": {
              "additionalProperties": false,
              "properties": {
                "method": {
                  "enum": [
                    "GET",
                    "POST",
                    "PUT",
                    "PATCH",
                    "DELETE",
                    "HEAD"
                  ],
                  "type": "string"
                },
                "queryParams": {
                  "properties": {
                    "q": {
                      "description": "Gene symbol, name or Ensembl id, e.g. BRCA1, EGFR, ENSG00000146648",
                      "type": "string"
                    }
                  },
                  "required": [
                    "q"
                  ],
                  "type": "object"
                },
                "type": {
                  "const": "http",
                  "type": "string"
                }
              },
              "required": [
                "type",
                "method"
              ],
              "type": "object"
            },
            "output": {
              "properties": {
                "example": {
                  "properties": {
                    "other_matches": {
                      "description": "Other candidates that matched the query, lower ranked",
                      "type": "array"
                    },
                    "query": {
                      "description": "The query as the server interpreted it",
                      "type": "string"
                    },
                    "source": {
                      "description": "Data source the values come from",
                      "type": "string"
                    },
                    "top_match": {
                      "description": "Top match",
                      "type": "object"
                    },
                    "url": {
                      "description": "Canonical URL",
                      "type": "string"
                    }
                  },
                  "required": [
                    "top_match"
                  ],
                  "type": "object"
                },
                "type": {
                  "const": "json",
                  "type": "string"
                }
              },
              "required": [
                "type"
              ],
              "type": "object"
            }
          },
          "required": [
            "input"
          ],
          "type": "object"
        }
      }
    },
    "iconUrl": "https://res.cloudinary.com/bdb-prod/image/upload/c_fill,ar_1:1,w_256,h_256,f_auto,q_auto/v1791811517/bazaar-icons/bc5e2b3d111ebbef.jpg",
    "lastUpdated": "2026-10-17T08:28:44.24Z",
    "quality": {
      "l30DaysTotalCalls": 2,
      "l30DaysUniquePayers": 2,
      "lastCalledAt": "2026-10-17T08:28:44.044Z"
    },
    "resource": "https://saylorinnovations.com/api/bio/target-search",
    "serviceName": "Saylor Innovations Data Desk",
    "tags": [
      "gene to disease associations",
      "open targets lookup",
      "drug target tractability",
      "ensembl id for gene symbol",
      "top diseases linked to a gene"
    ],
    "type": "http",
    "x402Version": 2
  },
  "source": "x402_bazaar",
  "summary": "Gene and drug-target lookup from Open Targets - Ensembl id, location, function, tractability by modality and top associated diseases with scores"
}

What the leaf hashes

{"body":"46bc31ef087b866b7656de99f38e2371538d086fc6d63ddce54d5a45f3ebad76","id":119405,"kind":"listing","method":"baseline/1","observed_us":1793025615306774,"prev":null,"subject":"x402_bazaar:https://saylorinnovations.com/api/bio/target-search","subject_kind":"source_record"}

Proof

Fold these into the leaf in order, hashing each sorted pair with keccak256, to reach the root of (296695 rows).

  1. 0xada1adadeb4c811b53476df7f3248372b85d8eebfc0ff3adf849fd446352e58d
  2. 0xe589ec92b09534a1ed0c4935cd2b68aa40e6ec0208741b4a70a95359225fdc7c
  3. 0x1de8c41440d16c36c17b0334cf2b2058922eb3e1c715199f59347865ea11ecb2
  4. 0xa77814b73e2b88e91871405d1fe79d8b25e3af6d384d8157c733b93784ebe3cc
  5. 0xb0c77f661b4c5d7676edf7784c1727bc44d72ae1871c34cd888fd744388a15ac
  6. 0x8a2ae663e6d6bcdc1a3586c7d204f0fd9a7808eb202c463c65f41e8b5fbcf7d0
  7. 0xd2ccbacd42427cb1ab3f5a1abd15b5617bfa512b6589c31f6e98778247de3503
  8. 0x2c0e64a63eb6855b75d2640e83e2c70753c390afc359671e2f5c210d8bbf1729
  9. 0xcf5b94bb64e3e01451b931dac0a13d7cbc61600a76eae700df5cfdea9ebec255
  10. 0xb5688486812d7136b27c2bdbc2ae09bc9ad3ac941f3ea900e81fe9d1958be50e
  11. 0x317c51a47b234292d19f812377ad1cc4d05ded07987c4ea1ac9ae1ad2b20f0d2
  12. 0x51f06c175a7c946ebe50ef243d6f9370a8fe85c996e53eff19ffcc4585ea8c18
  13. 0xe292b5a99219f136bce6647ce74b21240a1c7331d2475b1839220fd363c94217
  14. 0x3b4dba7d874fc323b0a364140a9c60f37bf547fe671897653118a9873fe03420
  15. 0x1a74ed3b3756b9cd946da49701bcec120ec88645013da99fa9eea60b39e1a570
  16. 0x123ec8bee20ddc55223eeef5a4f4d6c4b6416515adbb911c56759f5cde56e452
  17. 0xd0651cb9bc8155eb52b5247d506e74b8a935057dc190ba52091702ac25ed3a40
  18. 0x9a9024edb5069d88a324facb310a5ce8e495214bbaa968f077bede437390194f
  19. 0x9b9ce5b74b9bab5121612ef6b64920a8d453cbf311096a423eef9702747e868a
Day root
0xf43e8dcc3d451a4788b26be904c55e8c4c0fa75c9666796c51db38d37e2c0df8
Chained
0x702d5ac508f08b0d1accf36af25822d8e5660367494edd17a642fb61e158a57a
Published
On Arc Testnet, block 69251483: 0x495162f8936e19f0039918feebe6c307f327cd6bf8c37219620b1970041fa9ae

How to check it · This row as JSON