← The evidence ledger
Evidence row 119405
Observed , by baseline/1.
- Kind
- listing
- About
- source_record x402_bazaar:https://saylorinnovations.com/api/bio/target-search
- Recorded
- Previous row
- None: the first of its kind about this subject
- Body SHA-256
- 46bc31ef087b866b7656de99f38e2371538d086fc6d63ddce54d5a45f3ebad76
- Leaf
- 0xada1b52438a9a47ed3ef8071211e8a1a37afdfc673d309c10c08e41e2f994856
What was observed
{
"endpoints": [
[
"x402",
"https://saylorinnovations.com/api/bio/target-search"
]
],
"name": "Saylor Innovations Data Desk",
"owner_address": "0xa2a8df0f7caabea4e120a2568118f141569fc8aa",
"raw": {
"accepts": [
{
"amount": "10000",
"asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
"extra": {
"assetTransferMethod": "eip3009",
"facilitatorOnly": true,
"memo": "saylor:datadesk:opentargets-targ",
"name": "USD Coin",
"note": "Base settles through an x402 facilitator. Send payload.signature and payload.authorization (EIP-3009); there is no self-submitted path on this network.",
"version": "2"
},
"maxTimeoutSeconds": 120,
"network": "eip155:8453",
"payTo": "0xA2A8dF0f7CaaBEa4e120a2568118f141569fc8aa",
"scheme": "exact"
},
{
"amount": "10000",
"asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
"extra": {
"feePayer": "BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F",
"memo": "saylor:datadesk:opentargets-targ",
"reference": "Ajx85wsdPC6SJZLGiK7Fg9b35QDfBdmqZpYBx5tTtybK",
"session": "eyJhcnRpY2xlSWQiOiJkYXRhZGVzazpvcGVudGFyZ2V0cy10YXJnZXQiLCJyZWZlcmVuY2UiOiJBang4NXdzZFBDNlNKWkxHaUs3Rmc5YjM1UURmQmRtcVpwWUJ4NXRUdHliSyIsInJlY2lwaWVudCI6IjdMU2pmckpmOGZOc0I4VkE5dTdOM1dFbjI1c21RTHBvYjNTdnlVdlhhY3k3IiwibWludCI6IkVQakZXZGQ1QXVmcVNTcWVNMnFOMXh6eWJhcEM4RzR3RUdHa1p3eVREdDF2IiwibWluQW1vdW50IjoxMDAwMCwiZXhwIjoxNzkyMjI1ODQ0MTk2fQ.1ENY0Tqt75ZTF0nau2wfRrHrFF2Uf11I7NzV6lPx3DI"
},
"maxTimeoutSeconds": 120,
"network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
"payTo": "7LSjfrJf8fNsB8VA9u7N3WEn25smQLpob3SvyUvXacy7",
"scheme": "exact"
}
],
"description": "Gene and drug-target lookup from Open Targets - Ensembl id, location, function, tractability by modality and top associated diseases with scores",
"extensions": {
"bazaar": {
"info": {
"input": {
"method": "GET",
"queryParams": {
"q": "BRCA1"
},
"type": "http"
},
"output": {
"example": {
"other_matches": [
{
"description": "BRCA1 pseudogene 1",
"ensembl_id": "ENSG00000267595",
"symbol": "BRCA1P1"
},
{
"description": "BRCA1 interacting DNA helicase 1",
"ensembl_id": "ENSG00000136492",
"symbol": "BRIP1"
},
{
"description": "BRCA1 associated deubiquitinase 1",
"ensembl_id": "ENSG00000163930",
"symbol": "BAP1"
},
{
"description": "BRCA1 associated RING domain 1",
"ensembl_id": "ENSG00000138376",
"symbol": "BARD1"
}
],
"query": "BRCA1",
"source": "Open Targets Platform",
"top_match": {
"associated_disease_count": 1324,
"biotype": "protein_coding",
"ensembl_id": "ENSG00000012048",
"function": "E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microt…",
"location": {
"chromosome": "17",
"end": 43170245,
"start": 43044292,
"strand": "NEGATIVE"
},
"name": "BRCA1 DNA repair associated",
"symbol": "BRCA1",
"top_diseases": [
{
"association_score": 0.844,
"disease": "breast cancer",
"efo_id": "MONDO_0007254"
},
{
"association_score": 0.828,
"disease": "hereditary breast ovarian cancer syndrome",
"efo_id": "MONDO_0003582"
},
{
"association_score": 0.817,
"disease": "Fanconi anemia, complementation group S",
"efo_id": "MONDO_0054748"
},
{
"association_score": 0.811,
"disease": "ovarian cancer",
"efo_id": "MONDO_0008170"
},
{
"association_score": 0.8,
"disease": "breast neoplasm",
"efo_id": "MONDO_0021100"
},
{
"association_score": 0.799,
"disease": "breast-ovarian cancer, familial, susceptibility to, 1",
"efo_id": "MONDO_0011450"
},
{
"association_score": 0.788,
"disease": "ovarian neoplasm",
"efo_id": "MONDO_0021068"
},
{
"association_score": 0.779,
"disease": "cancer",
"efo_id": "MONDO_0004992"
}
],
"tractability_by_modality": {
"AB": [
"GO CC high conf"
],
"PR": [
"UniProt Ubiquitination",
"Database Ubiquitination",
"Small Molecule Binder"
],
"SM": [
"Druggable Family"
]
}
},
"url": "https://platform.opentargets.org/target/ENSG00000012048"
},
"type": "json"
}
},
"schema": {
"$schema": "https://json-schema.org/draft/2020-12/schema",
"properties": {
"input": {
"additionalProperties": false,
"properties": {
"method": {
"enum": [
"GET",
"POST",
"PUT",
"PATCH",
"DELETE",
"HEAD"
],
"type": "string"
},
"queryParams": {
"properties": {
"q": {
"description": "Gene symbol, name or Ensembl id, e.g. BRCA1, EGFR, ENSG00000146648",
"type": "string"
}
},
"required": [
"q"
],
"type": "object"
},
"type": {
"const": "http",
"type": "string"
}
},
"required": [
"type",
"method"
],
"type": "object"
},
"output": {
"properties": {
"example": {
"properties": {
"other_matches": {
"description": "Other candidates that matched the query, lower ranked",
"type": "array"
},
"query": {
"description": "The query as the server interpreted it",
"type": "string"
},
"source": {
"description": "Data source the values come from",
"type": "string"
},
"top_match": {
"description": "Top match",
"type": "object"
},
"url": {
"description": "Canonical URL",
"type": "string"
}
},
"required": [
"top_match"
],
"type": "object"
},
"type": {
"const": "json",
"type": "string"
}
},
"required": [
"type"
],
"type": "object"
}
},
"required": [
"input"
],
"type": "object"
}
}
},
"iconUrl": "https://res.cloudinary.com/bdb-prod/image/upload/c_fill,ar_1:1,w_256,h_256,f_auto,q_auto/v1791811517/bazaar-icons/bc5e2b3d111ebbef.jpg",
"lastUpdated": "2026-10-17T08:28:44.24Z",
"quality": {
"l30DaysTotalCalls": 2,
"l30DaysUniquePayers": 2,
"lastCalledAt": "2026-10-17T08:28:44.044Z"
},
"resource": "https://saylorinnovations.com/api/bio/target-search",
"serviceName": "Saylor Innovations Data Desk",
"tags": [
"gene to disease associations",
"open targets lookup",
"drug target tractability",
"ensembl id for gene symbol",
"top diseases linked to a gene"
],
"type": "http",
"x402Version": 2
},
"source": "x402_bazaar",
"summary": "Gene and drug-target lookup from Open Targets - Ensembl id, location, function, tractability by modality and top associated diseases with scores"
}What the leaf hashes
{"body":"46bc31ef087b866b7656de99f38e2371538d086fc6d63ddce54d5a45f3ebad76","id":119405,"kind":"listing","method":"baseline/1","observed_us":1793025615306774,"prev":null,"subject":"x402_bazaar:https://saylorinnovations.com/api/bio/target-search","subject_kind":"source_record"}Proof
Fold these into the leaf in order, hashing each sorted pair with keccak256, to reach the root of (296695 rows).
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- 0xe589ec92b09534a1ed0c4935cd2b68aa40e6ec0208741b4a70a95359225fdc7c
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- 0xb0c77f661b4c5d7676edf7784c1727bc44d72ae1871c34cd888fd744388a15ac
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- 0xd2ccbacd42427cb1ab3f5a1abd15b5617bfa512b6589c31f6e98778247de3503
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- 0xcf5b94bb64e3e01451b931dac0a13d7cbc61600a76eae700df5cfdea9ebec255
- 0xb5688486812d7136b27c2bdbc2ae09bc9ad3ac941f3ea900e81fe9d1958be50e
- 0x317c51a47b234292d19f812377ad1cc4d05ded07987c4ea1ac9ae1ad2b20f0d2
- 0x51f06c175a7c946ebe50ef243d6f9370a8fe85c996e53eff19ffcc4585ea8c18
- 0xe292b5a99219f136bce6647ce74b21240a1c7331d2475b1839220fd363c94217
- 0x3b4dba7d874fc323b0a364140a9c60f37bf547fe671897653118a9873fe03420
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- 0x9b9ce5b74b9bab5121612ef6b64920a8d453cbf311096a423eef9702747e868a
- Day root
- 0xf43e8dcc3d451a4788b26be904c55e8c4c0fa75c9666796c51db38d37e2c0df8
- Chained
- 0x702d5ac508f08b0d1accf36af25822d8e5660367494edd17a642fb61e158a57a
- Published
- On Arc Testnet, block 69251483: 0x495162f8936e19f0039918feebe6c307f327cd6bf8c37219620b1970041fa9ae